C₁₅H₁₉IO₃

Base Information

Chemical Name:C₁₅H₁₉IO₃
CAS No.:1027982-33-7
Molecular Formula:C₁₅H₁₉IO₃
Molecular Weight:374.219
Hs Code.:

C<sub>15</sub>H<sub>19</sub>IO<sub>3</sub>

Synonyms:C₁₅H₁₉IO₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₅H₁₉IO₃

Chemical Property:

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Technology Process of C₁₅H₁₉IO₃

There total 1 articles about C₁₅H₁₉IO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27913-58-2
4-(4-iodophenyl)butanoic acid

: 3282-30-2
pivaloyl chloride

: 1027982-33-7
C₁₅H₁₉IO₃

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jm960465t

Reference yield:

: 1027982-33-7
C₁₅H₁₉IO₃

: (2S,4R)-2-Butyl-4-[2-(4-cyclohept-2-enyl-phenyl)-ethyl]-pentanedioic acid 1-tert-butyl ester 5-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, from 0 deg C to RT, overnight

2: 1.) TiCl₄, Ti(O-iPr)4, i-Pr₂NEt / 1.) CH₂Cl₂, 0 deg C, 90 min, 2.) CH₂Cl₂, 0 deg C, overnight

3: 1.) aq. LiOH, H₂O₂, 2.) sodium sulfite, aq. NaHCO₃ / 1.) THF, 0 deg C, 3 h, 2.) THF, 2 h

4: 1.) 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.) THF, -78 deg C, 1 h, 2.) THF, 0 deg C, overnight

5: 300 mg / EDC, DMAP / tetrahydrofuran / Ambient temperature

6: 64 percent / n-Bu₄NCl, KOAc, Pd(OAc)2 / Ambient temperature

With titanium(IV) isopropylate; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; palladium diacetate; lithium hydroxide; n-butyllithium; tetrabutyl-ammonium chloride; dihydrogen peroxide; potassium acetate; titanium tetrachloride; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; sodium sulfite; In tetrahydrofuran;
DOI:10.1021/jm960465t

Reference yield:

: 1027982-33-7
C₁₅H₁₉IO₃

: 187827-32-3
(2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-(4-thiophen-3-yl-phenyl)-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, from 0 deg C to RT, overnight

2: 1.) TiCl₄, Ti(O-iPr)4, i-Pr₂NEt / 1.) CH₂Cl₂, 0 deg C, 90 min, 2.) CH₂Cl₂, 0 deg C, overnight

3: 1.) aq. LiOH, H₂O₂, 2.) sodium sulfite, aq. NaHCO₃ / 1.) THF, 0 deg C, 3 h, 2.) THF, 2 h

4: 1.) 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.) THF, -78 deg C, 1 h, 2.) THF, 0 deg C, overnight

5: 300 mg / EDC, DMAP / tetrahydrofuran / Ambient temperature

6: 240 mg / aq. Na₂CO₃, KBr, Pd(PPh₃)4 / toluene; ethanol / 6 h / 95 °C

7: 190 mg / Bu₄NF / dimethylformamide; tetrahydrofuran / 4 h / Ambient temperature

8: 135 mg / HOBt, EDC, N-methylmorpholine / tetrahydrofuran / Ambient temperature

With 4-methyl-morpholine; titanium(IV) isopropylate; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutyl ammonium fluoride; dihydrogen peroxide; titanium tetrachloride; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; potassium bromide; sodium sulfite; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm960465t