5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide

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Chemical Name:5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide
CAS No.:1380229-23-1
Molecular Formula:C₂₅H₂₀ClF₂N₇O₃S₂
Molecular Weight:604.061
Hs Code.:

Synonyms:5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide

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Chemical Property of 5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide

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Technology Process of 5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide

There total 15 articles about 5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2766-74-7
5-chlorothien-2-ylsulfonyl chloride

: 1380228-73-8
2,6-difluoro-N₁-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)benzene-1,3-diamine

: 1380229-23-1
5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 50 ℃; for 2h;

Reference yield:

: 1093101-52-0
6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine

: C₁₀H₇ClF₂N₂O₂S₂

: 1380229-23-1
5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1002/bkcs.10917

Reference yield:

: 385-00-2
2,6-difluorobenzoic acid

: 1380229-23-1
5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid; potassium nitrate / 24 h / 0 - 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

3.1: sodium azide / dichloromethane / 0.5 h / 20 °C

3.2: 3 h / Reflux

4.1: palladium on activated charcoal; hydrogen / methanol / 15 h

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

6.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 5 h / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C

8.1: palladium on activated charcoal; hydrogen / methanol / 1 h

9.1: pyridine / dichloromethane / 2 h / 50 °C

With pyridine; hydrogenchloride; sodium azide; oxalyl dichloride; sulfuric acid; palladium on activated charcoal; hydrogen; potassium nitrate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;