2,2'-(1,4-phenylene)bis(5-cyano-6-ethylthio-1-phenethyl-1,2,3,4-tetrahydropyrimidin-4-one)

Base Information

• Chemical Name: 2,2'-(1,4-phenylene)bis(5-cyano-6-ethylthio-1-phenethyl-1,2,3,4-tetrahydropyrimidin-4-one)
• CAS No.: 1258949-96-0
• Molecular Formula: C₃₆H₃₆N₆O₂S₂
• Molecular Weight: 648.853

Synonyms:2,2'-(1,4-phenylene)bis(5-cyano-6-ethylthio-1-phenethyl-1,2,3,4-tetrahydropyrimidin-4-one)

Chemical Property of 2,2'-(1,4-phenylene)bis(5-cyano-6-ethylthio-1-phenethyl-1,2,3,4-tetrahydropyrimidin-4-one)

Chemical Property:

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Technology Process of 2,2'-(1,4-phenylene)bis(5-cyano-6-ethylthio-1-phenethyl-1,2,3,4-tetrahydropyrimidin-4-one)

There total 3 articles about 2,2'-(1,4-phenylene)bis(5-cyano-6-ethylthio-1-phenethyl-1,2,3,4-tetrahydropyrimidin-4-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,2'-(1,4-phenylene)-bis(5-cyano-6-phenethylamino-3,4-dihydro-2H-1,3-thiazin-4-one) (1258949-91-5) + ethyl iodide (75-03-6) → 2,2'-(1,4-phenylene)bis(5-cyano-6-ethylthio-1-phenethyl-1,2,3,4-tetrahydropyrimidin-4-one) (1258949-96-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1515/znb-2010-0915

Reference yield:

2-cyano-3-mercapto-3-phenethylamino-acrylamide (1258949-89-1) → 2,2'-(1,4-phenylene)bis(5-cyano-6-ethylthio-1-phenethyl-1,2,3,4-tetrahydropyrimidin-4-one) (1258949-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / ethanol / 2.5 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1515/znb-2010-0915

Reference yield:

terephthalaldehyde, (623-27-8) → 2,2'-(1,4-phenylene)bis(5-cyano-6-ethylthio-1-phenethyl-1,2,3,4-tetrahydropyrimidin-4-one) (1258949-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / ethanol / 2.5 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1515/znb-2010-0915

upstream raw materials:

2-cyano-3-mercapto-3-phenethylamino-acrylamide

2,2'-(1,4-phenylene)-bis(5-cyano-6-phenethylamino-3,4-dihydro-2H-1,3-thiazin-4-one)

ethyl iodide

terephthalaldehyde,

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