4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalohydrazide

Base Information

Chemical Name:4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalohydrazide
CAS No.:1309588-09-7
Molecular Formula:C₂₂H₂₇N₇O₂S
Molecular Weight:453.568
Hs Code.:

Synonyms:4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalohydrazide

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Chemical Property of 4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalohydrazide

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Technology Process of 4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalohydrazide

There total 4 articles about 4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1309588-06-4
4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid

: 1309588-09-7
4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalohydrazide

Guidance literature:: 4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid; With thionyl chloride; for 4h; Reflux;

With hydrazine hydrate; In ethanol; for 6h; Reflux;
DOI:10.1007/s00044-010-9389-z

Reference yield:

: 15687-27-1,58560-75-1
ibuprofen

: 1309588-09-7
4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 5 °C

2.1: tetrahydrofuran / 12 h / Reflux

3.1: hydrogenchloride; potassium hydroxide / water / Reflux

4.1: ethanol / 4 h / Reflux

5.1: thionyl chloride / 4 h / Reflux

5.2: 6 h / Reflux

With hydrogenchloride; thionyl chloride; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1007/s00044-010-9389-z

Reference yield:

: 104400-52-4
2-(4-isobutylphenyl)propionic acid N-oxysuccinimide ester

: 1309588-09-7
4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 12 h / Reflux

2.1: hydrogenchloride; potassium hydroxide / water / Reflux

3.1: ethanol / 4 h / Reflux

4.1: thionyl chloride / 4 h / Reflux

4.2: 6 h / Reflux

With hydrogenchloride; thionyl chloride; potassium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1007/s00044-010-9389-z