4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid

Base Information

Chemical Name:4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid
CAS No.:1309588-06-4
Molecular Formula:C₂₂H₂₃N₃O₄S
Molecular Weight:425.508
Hs Code.:

Synonyms:4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid

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Chemical Property of 4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid

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Technology Process of 4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid

There total 3 articles about 4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 89-20-3
4-chlorophthalic acid

: 306963-82-6
5-(1-(4-isobutylphenyl)ethyl)-2H-1,2,4-triazole-3(4H)-thione

: 1309588-06-4
4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid

Guidance literature:: In ethanol; for 4h; Reflux;
DOI:10.1007/s00044-010-9389-z

Reference yield:

: 15687-27-1,58560-75-1
ibuprofen

: 1309588-06-4
4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide / tetrahydrofuran / 5 °C

2: tetrahydrofuran / 12 h / Reflux

3: hydrogenchloride; potassium hydroxide / water / Reflux

4: ethanol / 4 h / Reflux

With hydrogenchloride; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1007/s00044-010-9389-z

Reference yield:

: 104400-52-4
2-(4-isobutylphenyl)propionic acid N-oxysuccinimide ester

: 1309588-06-4
4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)phthalic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 12 h / Reflux

2: hydrogenchloride; potassium hydroxide / water / Reflux

3: ethanol / 4 h / Reflux

With hydrogenchloride; potassium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1007/s00044-010-9389-z