2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester
• CAS No.: 228110-76-7
• Molecular Formula: C₄₃H₃₉N₉O₆S₄
• Molecular Weight: 906.103
• Mol file: 228110-76-7.mol

Synonyms:2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester

Chemical Property of 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester

There total 20 articles about 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1,2,3-benzotriazol-1-yl-6 triphenylmethylaminohexyl carboxylate (288590-33-0) + 2-{[2-({2-[(2-amino-thiazole-4-carbonyl)-amino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carboxylic acid ethyl ester → 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester (228110-76-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 10h;

DOI:10.1016/S0223-5234(00)01181-8

Reference yield:

6-(triphenylmethylamino)hexanoic acid (5612-13-5) → 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester (228110-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / CH₂Cl₂ / 3 h / 20 °C

2: 63 percent / NEt₃ / dimethylformamide / 10 h / 60 °C

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(00)01181-8

Reference yield:

ethyl 6-triphenylmethylaminohexanoic acid (228110-68-7) → 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester (228110-76-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 24.8 g / aq. NaOH / ethanol / 4 h / 20 °C

2: DCC / CH₂Cl₂ / 3 h / 20 °C

3: 63 percent / NEt₃ / dimethylformamide / 10 h / 60 °C

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(00)01181-8

upstream raw materials:

2-aminothiazole-4-carboxylate

2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carboxylic acid

1,2,3-benzotriazol-1-yl-6 triphenylmethylaminohexyl carboxylate

ethyl 6-aminocaproate hydrochloride

Downstream raw materials:

C₄₆H₄₇N₁₁O₅S₄

C₄₄H₄₂N₁₀O₇S₄

2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid