2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid

Base Information

• Chemical Name: 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid
• CAS No.: 288590-42-1
• Molecular Formula: C₄₁H₃₅N₉O₆S₄
• Molecular Weight: 878.05
• Mol file: 288590-42-1.mol

Synonyms:2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid

Chemical Property of 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid

There total 14 articles about 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester (228110-76-7) → 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid (288590-42-1)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 12h;

DOI:10.1016/S0968-0896(00)00029-8

Reference yield:

ethyl 6-aminocaproate hydrochloride (3633-17-8) → 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid (288590-42-1)

Guidance literature:

Multi-step reaction with 5 steps

1: NEt₃ / CH₂Cl₂ / 3 h / 20 °C

2: 24.8 g / aq. NaOH / ethanol / 4 h / 20 °C

3: DCC / CH₂Cl₂ / 3 h / 20 °C

4: 63 percent / NEt₃ / dimethylformamide / 10 h / 60 °C

5: aq. NaOH / ethanol / 12 h / 20 °C

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(00)01181-8

Reference yield:

6-(triphenylmethylamino)hexanoic acid (5612-13-5) → 2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid (288590-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC / CH₂Cl₂ / 3 h / 20 °C

2: 63 percent / NEt₃ / dimethylformamide / 10 h / 60 °C

3: aq. NaOH / ethanol / 12 h / 20 °C

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(00)01181-8

upstream raw materials:

2-[(2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carbonyl)-amino]-thiazole-4-carboxylic acid ethyl ester

ethyl 6-aminocaproate hydrochloride

trityl chloride

6-(triphenylmethylamino)hexanoic acid

Downstream raw materials:

C₄₆H₄₇N₁₁O₅S₄

C₄₄H₄₂N₁₀O₇S₄