N²,N⁶-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine

Base Information

• Chemical Name: N²,N⁶-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine
• CAS No.: 425394-09-8
• Molecular Formula: C₄₄H₃₈N₆O₇
• Molecular Weight: 762.822

Synonyms:N²,N⁶-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine

Chemical Property of N²,N⁶-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine

Chemical Property:

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Technology Process of N²,N⁶-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine

There total 3 articles about N²,N⁶-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.1%

4,4'-dimethoxytrityl chloride (40615-36-9) + N2,N6-dibenzoyl-9-(α-L-threofuranosyl)-2,6-diaminopurine (425394-08-7) → N2,N6-dibenzoyl-9-{2'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine (425394-11-2) + N2,N6-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine (425394-09-8) + N2,N6-dibenzoyl-9-{2',3'-O-bis[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine

Guidance literature:

With 2,6-dimethylpyridine; silver trifluoromethanesulfonate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/hlca.200290000

Reference yield:

2,6-diaminopurine-N2,N6-dibenzoate (51173-57-0) → N2,N6-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine (425394-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 59.1 percent / BSA; TMS-Tf / acetonitrile / 3 h / 65 °C

2: 86.6 percent / NaOH; water / tetrahydrofuran; methanol / 0.17 h / 0 °C

3: 40.1 percent / 2,6-lutidine; Ag-Tf / dimethylformamide; CH₂Cl₂ / 20 °C

With 2,6-dimethylpyridine; benzenesulfonamide; sodium hydroxide; water; silver trifluoromethanesulfonate; trimethyl((trifluoromethyl)sulfonyl)silane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/hlca.200290000

Reference yield:

N2,N6-dibenzoyl-9-(2',3'-di-O-benzoyl-α-L-threofuranosyl)-2,6-diaminopurine (425394-07-6) → N2,N6-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine (425394-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 86.6 percent / NaOH; water / tetrahydrofuran; methanol / 0.17 h / 0 °C

2: 40.1 percent / 2,6-lutidine; Ag-Tf / dimethylformamide; CH₂Cl₂ / 20 °C

With 2,6-dimethylpyridine; sodium hydroxide; water; silver trifluoromethanesulfonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200290000

upstream raw materials:

4,4'-dimethoxytrityl chloride

N²,N⁶-dibenzoyl-9-(α-L-threofuranosyl)-2,6-diaminopurine

2,6-diaminopurine-N²,N⁶-dibenzoate

N²,N⁶-dibenzoyl-9-(2',3'-di-O-benzoyl-α-L-threofuranosyl)-2,6-diaminopurine

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