51173-57-0

Upstream product

• 108-24-7 acetic anhydride 
• 1904-98-9 2,6-diaminopurine 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 425394-07-6 N²,N⁶-dibenzoyl-9-(2',3'-di-O-benzoyl-α-L-threofuranosyl)-2,6-diaminopurine 
• 425394-09-8 N²,N⁶-dibenzoyl-9-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine 
• 425394-11-2 N²,N⁶-dibenzoyl-9-{2'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}-2,6-diaminopurine 
• 425394-08-7 N²,N⁶-dibenzoyl-9-(α-L-threofuranosyl)-2,6-diaminopurine 

Relevant academic research and scientific papers

Base-Pairing Properties of Double-Headed Nucleotides

Nucleotides that contain two nucleobases (double-headed nucleotides) have the potential to condense the information of two separate nucleotides into one. This presupposes that both bases must successfully pair with a cognate strand. Here, double-headed nucleotides that feature cytosine, guanine, thymine, adenine, hypoxanthine, and diaminopurine linked to the C2′-position of an arabinose scaffold were developed and examined in full detail. These monomeric units were efficiently prepared by convergent synthesis and incorporated into DNA oligonucleotides by means of the automated phosphoramidite method. Their pairing efficiency was assessed by UV-based melting-temperature analysis in several contexts and extensive molecular dynamics studies. Altogether, the results show that these double-headed nucleotides have a well-defined structure and invariably behave as functional dinucleotide mimics in DNA duplexes.

Prolinamides of Aminouracils, Organocatalyst Modifiable by Complementary Modules

We report the synthesis and evaluation of prolinamide organocatalysts that incorporate aminouracils. The features of these catalysts are enhanced NH acidity of the amide because of the electron-withdrawing nature of the heterocycle, an additional hydrogen-bond donor at the α or β positions of this functional group (using 6-aminouracil or 5,6-diaminouracil respectively), and it can be recovered due to its low solubility and used again without decreasing the enantioselectivity. A unique feature of these systems is the self-assembly capability with complementary modules by Watson–Crick interactions. These supramolecular adducts behave differently from the catalyst alone, some of them have lower performance but others improve the selectivity of the product. Therefore, this approach avoids the synthesis of many catalysts.