tert-butyl 3-{5-(methanesulfonylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate

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Chemical Name:tert-butyl 3-{5-(methanesulfonylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate
CAS No.:197707-84-9
Molecular Formula:C₂₇H₃₇NO₆S
Molecular Weight:503.66
Hs Code.:

Synonyms:tert-butyl 3-{5-(methanesulfonylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate

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Chemical Property of tert-butyl 3-{5-(methanesulfonylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate

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Technology Process of tert-butyl 3-{5-(methanesulfonylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate

There total 12 articles about tert-butyl 3-{5-(methanesulfonylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 124-63-0
methanesulfonyl chloride

: 134577-85-8
t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-aminobenzen-2-yl]propionate

: 197707-84-9
tert-butyl 3-{5-(methanesulfonylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 197707-84-9
tert-butyl 3-{5-(methanesulfonylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate

Guidance literature:: Multi-step reaction with 9 steps

1: conc. sulfuric acid / 1 h / Heating

2: AlCl₃ / 1,2-dichloro-ethane / 2.5 h / 15 °C

3: 5N aq. NaOH / methanol / 1 h / 25 °C

4: NaBH₄ / methanol / 1 h / 25 - 65 °C

5: 73 percent / KCl / dimethylsulfoxide / 4 h / 170 °C

6: 92 percent / triethylamine / CH₂Cl₂ / 1 h

7: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

8: 78 percent / aq. K₂CO₃ / methanol / 16 h / 25 °C

9: 91 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; sulfuric acid; potassium chloride; sodium hydride; potassium carbonate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 128577-60-6
(5E)-6-(4-Methoxyphenyl)-5-hexen-1-ol

: 197707-84-9
tert-butyl 3-{5-(methanesulfonylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / triethylamine / CH₂Cl₂ / 1 h

2: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

3: 78 percent / aq. K₂CO₃ / methanol / 16 h / 25 °C

4: 91 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With sodium hydride; potassium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(97)00089-8