1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone

Base Information

• Chemical Name: 1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone
• CAS No.: 1126431-42-2
• Molecular Formula: C₁₃H₁₀Cl₂N₂O
• Molecular Weight: 281.141
• Mol file: 1126431-42-2.mol

Synonyms:1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone

Chemical Property of 1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone

There total 1 articles about 1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

2-chloro-4-methylpyrimidine (13036-57-2) + methyl 4-chloro-3-methylbenzoate (91367-05-4) → 1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone (1126431-42-2)

Guidance literature:

methyl 4-chloro-3-methylbenzoate; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

2-chloro-4-methylpyrimidine; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield: 4.0%

ethyl-2-thiourea (625-53-6) + 1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone (1126431-42-2) → 4-(4-chloro-3-methylphenyl)-5-(2-chloro-4-pyrimidinyl)-N-ethyl-1,3-thiazol-2-amine (1126431-41-1)

Guidance literature:

1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone; With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 0.5h;

ethyl-2-thiourea; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

upstream raw materials:

2-chloro-4-methylpyrimidine

methyl 4-chloro-3-methylbenzoate

Downstream raw materials:

4-(4-chloro-3-methylphenyl)-5-(2-chloro-4-pyrimidinyl)-N-ethyl-1,3-thiazol-2-amine