91367-05-4

Basic information

• Product Name: METHYL 4-CHLORO-3-METHYLBENZOATE
• Synonyms: 4-Chloro-3-methylbenzoic acid methyl ester~4-Chloro-m-toluic acid methyl ester;4-CHLORO-3-METHYLBENZOIC ACID METHYL ESTER;4-chloro-m-toluic acid methyl ester;3-METHYL-4-CHLOROBENZOICACIDMETHYLESTER;2-Chloro-5-(methoxycarbonyl)toluene;2-Chloro-5-(methoxycarbonyl)toluene, Methyl 4-chloro-m-toluate;METHYL 4-CHLORO-3-METHYLBENZOATE
• CAS NO: 91367-05-4
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• Product Categories: Aromatic Esters;Benzoic acid;Acids & Esters;Chlorine Compounds
• Mol File: 91367-05-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 247 °C at 760 mmHg
• Flash Point: 113.6 °C
• Appearance: /
• Density: 1.21
• Vapor Pressure: 0.0263mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 4-CHLORO-3-METHYLBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-CHLORO-3-METHYLBENZOATE(91367-05-4)
• EPA Substance Registry System: METHYL 4-CHLORO-3-METHYLBENZOATE(91367-05-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 91367-05-4(Hazardous Substances Data)

Usage

General Description

Methyl 4-Chloro-3-Methylbenzoate is a chemical compound having the molecular formula C9H9ClO2. It falls into the category of aromatic esters and exhibits a molecular weight of 184.62. Generally, it comes in the form of a light yellow liquid and known for its applications in various industrial processes. However, the specific properties such as melting point, boiling point, density, and other physical characteristics can vary according to the conditions it's exposed to. Like any other chemical compound, safety measures should be adhered to while handling Methyl 4-Chloro-3-Methylbenzoate, to prevent any potential hazardous implications.

InChI:InChI=1/C9H9ClO2/c1-6-5-7(9(11)12-2)3-4-8(6)10/h3-5H,1-2H3

Upstream product

• 18595-14-7 methyl 4-amino-3-methylbenzoate 
• 67-56-1 methanol 
• 7697-29-2 4-chloro-3-methylbenzoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 220464-68-6 methyl 3-(bromomethyl)-4-chlorobenzoate 
• 651058-97-8 2-chloro-5-(methoxycarbonyl)benzoic acid 
• 1044920-98-0 methyl 4-chloro-3-formyl-benzoate 

Relevant articles and documents

Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents

A series of 2-(1H-imidazol-2-yl) pyridine derivatives (CLW01-CLW31) have been designed and synthesized, and they were screened for BRAF kinase inhibitory activity. Besides, their biological activities were evaluated in vitro and in vivo. All the compounds were reported for the first time, and compounds CLW14 and CLW27 displayed the most potent antiproliferative activity against cell line A375 in vitro, with IC50 values of 4.26 and 2.93 1/4M, respectively, which were comparable with the positive control Sorafenib. Those two compounds were further evaluated for the in vivo efficacy using an A375 xenograft nude mice model. The results showed that the growth of A375 cancer cells xenografts was suppressed by factors of 35.68% and 42.50% (percent tumor growth inhibition values) after intragastric (ig) administration of compound CLW14 and CLW27 at concentration of 50 mg/kg. Thus they may be promising lead compounds to be developed as an alternative for current Sorafenib therapy.

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.