91367-05-4

Basic information

• Product Name: METHYL 4-CHLORO-3-METHYLBENZOATE
• Synonyms: 4-Chloro-3-methylbenzoic acid methyl ester~4-Chloro-m-toluic acid methyl ester;4-CHLORO-3-METHYLBENZOIC ACID METHYL ESTER;4-chloro-m-toluic acid methyl ester;3-METHYL-4-CHLOROBENZOICACIDMETHYLESTER;2-Chloro-5-(methoxycarbonyl)toluene;2-Chloro-5-(methoxycarbonyl)toluene, Methyl 4-chloro-m-toluate;METHYL 4-CHLORO-3-METHYLBENZOATE
• CAS NO: 91367-05-4
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• Product Categories: Aromatic Esters;Benzoic acid;Acids & Esters;Chlorine Compounds
• Mol File: 91367-05-4.mol

Chemical Properties

• Boiling Point: 247 °C at 760 mmHg
• Flash Point: 113.6 °C
• Appearance: /
• Density: 1.21
• Vapor Pressure: 0.0263mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 4-CHLORO-3-METHYLBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-CHLORO-3-METHYLBENZOATE(91367-05-4)
• EPA Substance Registry System: METHYL 4-CHLORO-3-METHYLBENZOATE(91367-05-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 91367-05-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 4-CHLORO-3-METHYLBENZOATE is used as an intermediate in the synthesis of various pharmaceutical compounds for its aromatic ester properties, contributing to the development of new drugs.
Used in Agrochemical Industry:
METHYL 4-CHLORO-3-METHYLBENZOATE is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, due to its chemical reactivity and stability.
Used in Fragrance Industry:
METHYL 4-CHLORO-3-METHYLBENZOATE is used as a raw material in the creation of fragrances and perfumes, leveraging its aromatic characteristics to enhance scent profiles.
Used in Dye and Pigment Industry:
METHYL 4-CHLORO-3-METHYLBENZOATE is used as a component in the formulation of dyes and pigments, taking advantage of its color properties and chemical stability.

InChI:InChI=1/C9H9ClO2/c1-6-5-7(9(11)12-2)3-4-8(6)10/h3-5H,1-2H3

Upstream product

• 7697-29-2 4-chloro-3-methylbenzoic acid 
• 74-88-4 methyl iodide 
• 18595-14-7 methyl 4-amino-3-methylbenzoate 
• 67-56-1 methanol 

Downstream Products

• 220464-68-6 methyl 3-(bromomethyl)-4-chlorobenzoate 
• 1126431-42-2 1-(4-chloro-3-methylphenyl)-2-(2-chloro-4-pyrimidinyl)ethanone 
• 1233333-62-4 2-(4-Chloro-3-methyl-phenyl)-propan-2-ol 
• 1044920-98-0 methyl 4-chloro-3-formyl-benzoate 
• 651058-97-8 2-chloro-5-(methoxycarbonyl)benzoic acid 

Relevant articles and documents

Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents

A series of 2-(1H-imidazol-2-yl) pyridine derivatives (CLW01-CLW31) have been designed and synthesized, and they were screened for BRAF kinase inhibitory activity. Besides, their biological activities were evaluated in vitro and in vivo. All the compounds were reported for the first time, and compounds CLW14 and CLW27 displayed the most potent antiproliferative activity against cell line A375 in vitro, with IC50 values of 4.26 and 2.93 1/4M, respectively, which were comparable with the positive control Sorafenib. Those two compounds were further evaluated for the in vivo efficacy using an A375 xenograft nude mice model. The results showed that the growth of A375 cancer cells xenografts was suppressed by factors of 35.68% and 42.50% (percent tumor growth inhibition values) after intragastric (ig) administration of compound CLW14 and CLW27 at concentration of 50 mg/kg. Thus they may be promising lead compounds to be developed as an alternative for current Sorafenib therapy.

5-ALKYLOXY-INDOLIN-2-ONE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPY

The present invention relates to derivatives of 5-alkyloxy-indolin-2-one, their method of production and their therapeutic applications. These novel derivatives have affinity and selectivity for the V2 receptors of vasopressin (“V2 receptors”) and can therefore constitute active principles of pharmaceutical compositions.

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.

DIARYL ACETIC ACID DERIVATIVES AND THE PREPARATION THEREOF

The invention relates to compounds of the general formula (I), wherein R stands for nitro group or -COOR1 group, wherein R1 stands for hydrogen atom or for C1-4 straight or branched alkyl group, R2 stands for hy