lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate

Base Information

• Chemical Name: lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate
• CAS No.: 98151-68-9
• Molecular Formula: C₃₉H₃₇N₅O₁₀PS*Li
• Molecular Weight: 805.731

Synonyms:lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate

Chemical Property of lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate

Chemical Property:

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Technology Process of lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate

There total 6 articles about lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S,S-diphenyl dithiophosphate (98151-67-8) → lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate (98151-68-9)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; for 0.333333h;

DOI:10.1039/P19850000997

Reference yield:

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) → lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate (98151-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / DMS / pyridine / 2 h

2: 87 percent / 1M aqueous LiOH / dioxane / 0.33 h

With lithium hydroxide; 2,3-dimercapto-succinic acid; In 1,4-dioxane; pyridine;

DOI:10.1039/P19850000997

Reference yield:

2-N-(4,4'-dimethoxytrityl)-2',3'-di-O-methoxymethyleneguanosine (98151-72-5) → lithium 2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S-phenythiophosphate (98151-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / DMS / pyridine / 2 h

2: 87 percent / 1M aqueous LiOH / dioxane / 0.33 h

With lithium hydroxide; 2,3-dimercapto-succinic acid; In 1,4-dioxane; pyridine;

DOI:10.1039/P19850000997

upstream raw materials:

2-N-(4,4'-dimethoxytrityl)-2',3'-O-methoxymethyleneguanosine-5' S,S-diphenyl dithiophosphate

cyclohexylammonium S,S-diphenyl phosphorodithioate

2-N-(4,4'-dimethoxytrityl)-2',3'-di-O-methoxymethyleneguanosine

5'-O-acetyl-2-N-(4,4'-dimethoxytrityl)guanosine

Downstream raw materials:

2-N-(4,4'-dimethoxytrityl)-2',3'-methoxymethylene-7-methylguanosine-5' S-phenylthiophosphate inner salt

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