Technology Process of N,N-diallyl-3-((2R,4S,5R,6S)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl)-5-methoxyaniline
There total 5 articles about N,N-diallyl-3-((2R,4S,5R,6S)-4,5-dimethoxy-2,6-dimethylnon-7-yn-1-yl)-5-methoxyaniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethyl borane; tri-n-butyl-tin hydride;
In
tetrahydrofuran; toluene;
at 20 ℃;
for 1h;
DOI:10.1021/ol2019828
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 2 h / -78 - 20 °C / Inert atmosphere
1.2: 1 h / -78 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
2.2: 0.25 h / 20 °C / Inert atmosphere
2.3: 0.25 h / 20 °C / Inert atmosphere
3.1: triethyl borane; tri-n-butyl-tin hydride / tetrahydrofuran; toluene / 1 h / 20 °C
With
triethyl borane; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; toluene; pentane;
3.1: Barton deoxygenation;
DOI:10.1021/ol2019828
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 2 h / -78 - 20 °C / Inert atmosphere
1.2: 1 h / -78 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
2.2: 0.25 h / 20 °C / Inert atmosphere
2.3: 0.25 h / 20 °C / Inert atmosphere
3.1: triethyl borane; tri-n-butyl-tin hydride / tetrahydrofuran; toluene / 1 h / 20 °C
With
triethyl borane; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; toluene; pentane;
3.1: Barton deoxygenation;
DOI:10.1021/ol2019828
