4-[(S)-6-benzyloxycarbonylamino-3-dimethylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Chemical Name:4-[(S)-6-benzyloxycarbonylamino-3-dimethylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
CAS No.:928850-95-7
Molecular Formula:C₃₅H₄₂N₄O₅
Molecular Weight:598.742
Hs Code.:

Synonyms:4-[(S)-6-benzyloxycarbonylamino-3-dimethylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of 4-[(S)-6-benzyloxycarbonylamino-3-dimethylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of 4-[(S)-6-benzyloxycarbonylamino-3-dimethylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about 4-[(S)-6-benzyloxycarbonylamino-3-dimethylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[(S)-3-amino-6-benzyloxycarbonylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester hydrochloride salt

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 928850-95-7
4-[(S)-6-benzyloxycarbonylamino-3-dimethylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With (polystyryl)trimethylammonium cyanoborohydride; In methanol; water; at 20 ℃;
DOI:10.1021/jm061143k

Reference yield:

: 928850-95-7
4-[(S)-6-benzyloxycarbonylamino-3-dimethylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

: {(S)-4-amino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 20 °C

2.1: piperidine / dimethylformamide / 0.5 h / 20 °C

3.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 0.5 h / cooling

3.2: 45 percent / diisopropylethylamine / dimethylformamide / 0 - 20 °C

4.1: triflic acid; trifluoroacetic acid

With piperidine; trifluorormethanesulfonic acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm061143k

Reference yield:

: 928850-95-7
4-[(S)-6-benzyloxycarbonylamino-3-dimethylamino-hexanoyl]-piperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

: 928850-81-1
{4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 20 °C

2.1: piperidine / dimethylformamide / 0.5 h / 20 °C

3.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 0.5 h / cooling

3.2: 45 percent / diisopropylethylamine / dimethylformamide / 0 - 20 °C

With piperidine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm061143k