{4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

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Chemical Name:{4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium
CAS No.:928850-81-1
Molecular Formula:C₄₅H₅₇Cl₂N₆O₇S
Molecular Weight:896.956
Hs Code.:

{4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

Synonyms:{4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

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Chemical Property of {4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

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Technology Process of {4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

There total 6 articles about {4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 635698-09-8
1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid

: [(S)-4-benzyloxycarbonylamino-1-(2-oxo-2-piperazin-1-ylethyl)-butyl]-trimethyl-ammonium iodide

: 928850-81-1
{4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

Guidance literature:: 1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 0.5h; cooling;

[(S)-4-benzyloxycarbonylamino-1-(2-oxo-2-piperazin-1-ylethyl)-butyl]-trimethyl-ammonium iodide; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm061143k

Reference yield:

: 188440-21-3
3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride

: 928850-81-1
{4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

Guidance literature:: Multi-step reaction with 3 steps

1.1: K₂CO₃ / dimethylformamide / 18 h / 20 °C

1.2: KI; K₂CO₃ / acetone / 7 h / Heating

2.1: LiOH; H₂O / tetrahydrofuran; methanol / 4 h / Heating

3.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 0.5 h / cooling

3.2: 45 percent / diisopropylethylamine / dimethylformamide / 0 - 20 °C

With lithium hydroxide; water; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm061143k

Reference yield:

: 635697-88-0
1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester

: 928850-81-1
{4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiOH; H₂O / tetrahydrofuran; methanol / 4 h / Heating

2.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 0.5 h / cooling

2.2: 45 percent / diisopropylethylamine / dimethylformamide / 0 - 20 °C

With lithium hydroxide; water; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm061143k