(E)-3-{4-[1-methyl-1-(5-methyloxazol-2-yl)ethyl]benzenesulfonyl}acrylonitrile

Base Information

Chemical Name:(E)-3-{4-[1-methyl-1-(5-methyloxazol-2-yl)ethyl]benzenesulfonyl}acrylonitrile
CAS No.:1394819-43-2
Molecular Formula:C₁₆H₁₆N₂O₃S
Molecular Weight:316.381
Hs Code.:

Synonyms:(E)-3-{4-[1-methyl-1-(5-methyloxazol-2-yl)ethyl]benzenesulfonyl}acrylonitrile

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Chemical Property of (E)-3-{4-[1-methyl-1-(5-methyloxazol-2-yl)ethyl]benzenesulfonyl}acrylonitrile

Chemical Property:

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Technology Process of (E)-3-{4-[1-methyl-1-(5-methyloxazol-2-yl)ethyl]benzenesulfonyl}acrylonitrile

There total 4 articles about (E)-3-{4-[1-methyl-1-(5-methyloxazol-2-yl)ethyl]benzenesulfonyl}acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1365091-34-4
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-prop-2-ynylisobutyramide

: 1394819-43-2
(E)-3-{4-[1-methyl-1-(5-methyloxazol-2-yl)ethyl]benzenesulfonyl}acrylonitrile

Guidance literature:: gold(III) chloride; In [D₃]acetonitrile; for 96h;

Reference yield:

: 32454-35-6
2-(4-bromophenyl)-2-methylpropionic acid

: 1394819-43-2
(E)-3-{4-[1-methyl-1-(5-methyloxazol-2-yl)ethyl]benzenesulfonyl}acrylonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere

1.2: 0.33 h

1.3: 0.25 h

2.1: acetic acid / water; methanol / 20 °C

2.2: 1 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h

4.1: gold(III) chloride / [D₃]acetonitrile / 96 h

With benzotriazol-1-ol; acetic acid; phenyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; gold(III) chloride; In tetrahydrofuran; methanol; dichloromethane; [D₃]acetonitrile; water; toluene;

Reference yield:

: C₁₀H₁₀O₄S^(2-)*2Li⁽¹⁺⁾

: 1394819-43-2
(E)-3-{4-[1-methyl-1-(5-methyloxazol-2-yl)ethyl]benzenesulfonyl}acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / water; methanol / 20 °C

1.2: 1 h

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h

3.1: gold(III) chloride / [D₃]acetonitrile / 96 h

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; gold(III) chloride; In methanol; dichloromethane; [D₃]acetonitrile; water;