(S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride

Base Information

• Chemical Name: (S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride
• CAS No.: 130106-16-0
• Molecular Formula: C₁₆H₂₀N₂O₅
• Molecular Weight: 320.345

Synonyms:(S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride

Chemical Property of (S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride

Chemical Property:

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Technology Process of (S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride

There total 4 articles about (S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(S)-2-Benzyloxycarbonylamino-3-(4-chloro-butyrylamino)-propionic acid methyl ester (130106-15-9) → (S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride (130106-16-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1021/jm980071x

Reference yield:

(S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid (35761-26-3) → (S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride (130106-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / HCl gas / 12 h / Ambient temperature

2: 87 percent / NEt₃ / CH₂Cl₂ / 4 h / Ambient temperature

3: 56 percent / NaH / dimethylformamide / 4 h / Ambient temperature

With hydrogenchloride; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980071x

Reference yield:

methyl (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride (35761-27-4,96192-93-7) → (S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride (130106-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NEt₃ / CH₂Cl₂ / 4 h / Ambient temperature

2: 56 percent / NaH / dimethylformamide / 4 h / Ambient temperature

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980071x

upstream raw materials:

(S)-2-Benzyloxycarbonylamino-3-(4-chloro-butyrylamino)-propionic acid methyl ester

(S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid

methyl (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride

Downstream raw materials:

(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester

((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

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