((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

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Chemical Name:((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester
CAS No.:199005-67-9
Molecular Formula:C₃₀H₄₀N₄O₆
Molecular Weight:552.671
Hs Code.:

Synonyms:((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

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Chemical Property of ((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

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Technology Process of ((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

There total 6 articles about ((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130106-16-0
(S)-2-benzyloxycarbonylamino-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester hydrochloride

: 199005-67-9
((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂, HCl / 10percent Pd/C / methanol / 2 h

2: Et₃N / dimethylformamide; CH₂Cl₂ / Ambient temperature

3: LiCl, NaBH₄ / tetrahydrofuran; ethanol / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980071x

Reference yield:

: 130106-15-9
(S)-2-Benzyloxycarbonylamino-3-(4-chloro-butyrylamino)-propionic acid methyl ester

: 199005-67-9
((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 56 percent / NaH / dimethylformamide / 4 h / Ambient temperature

2: 100 percent / H₂, HCl / 10percent Pd/C / methanol / 2 h

3: Et₃N / dimethylformamide; CH₂Cl₂ / Ambient temperature

4: LiCl, NaBH₄ / tetrahydrofuran; ethanol / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydride; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980071x

Reference yield:

: 199005-66-8
(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-3-(2-oxo-pyrrolidin-1-yl)-propionic acid methyl ester

: 199005-67-9
((S)-1-{(S)-1-[(S)-1-Hydroxymethyl-2-(2-oxo-pyrrolidin-1-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester

Guidance literature:: With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; Yield given; Ambient temperature;
DOI:10.1021/jm980071x