5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid

Base Information

Chemical Name:5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid
CAS No.:1399119-66-4
Molecular Formula:C₁₆H₁₁FN₂O₄
Molecular Weight:314.273
Hs Code.:

Synonyms:5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid

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Chemical Property of 5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid

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Technology Process of 5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid

There total 7 articles about 5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

: 1401681-62-6
5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester

: 1399119-66-4
5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 55 ℃; for 0.916667h;

Reference yield:

: 709-45-5
2-fluoro-5-bromomethyl benzoic acid methyl ester

: 1399119-66-4
5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; sulfuric acid / toluene / 0.67 h / Reflux

1.2: 3 h / 140 °C

1.3: 0.5 h / 70 - 100 °C

2.1: lithium hydroxide / water; methanol; tetrahydrofuran / 0.92 h / 55 °C

With sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: 2967-93-3
2-fluoro-5-methyl benzoic acid methyl ester

: 1399119-66-4
5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Inert atmosphere; Reflux

2.1: 1,1,1,3,3,3-hexamethyl-disilazane; sulfuric acid / toluene / 0.67 h / Reflux

2.2: 3 h / 140 °C

2.3: 0.5 h / 70 - 100 °C

3.1: lithium hydroxide / water; methanol; tetrahydrofuran / 0.92 h / 55 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; water; toluene;