Technology Process of 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester
There total 5 articles about 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,2,3,4-tetrahydro-quinazoline-2,4-dione;
With
sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane;
In
toluene;
for 5h;
Reflux;
2-fluoro-5-bromomethyl benzoic acid methyl ester;
In
toluene;
at 140 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Inert atmosphere; Reflux
2.1: 1,1,1,3,3,3-hexamethyl-disilazane; sulfuric acid / toluene / 0.67 h / Reflux
2.2: 3 h / 140 °C
2.3: 0.5 h / 70 - 100 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrachloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / 3 h / Reflux
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetonitrile; tetrachloromethane / 1.5 h / Reflux
3.1: 1,1,1,3,3,3-hexamethyl-disilazane; sulfuric acid / toluene / 8 h / Inert atmosphere
3.2: 3 h / Inert atmosphere; Heating
3.3: 0.5 h / 70 - 100 °C / Inert atmosphere
With
N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane;
In
tetrachloromethane; toluene; acetonitrile;
DOI:10.1039/c8ob00286j
