5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester

Base Information

Chemical Name:5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester
CAS No.:1401681-62-6
Molecular Formula:C₁₇H₁₃FN₂O₄
Molecular Weight:328.3
Hs Code.:

Synonyms:5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester

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Chemical Property of 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester

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Technology Process of 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester

There total 5 articles about 5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.8%

: 86-96-4
1,2,3,4-tetrahydro-quinazoline-2,4-dione

: 709-45-5
2-fluoro-5-bromomethyl benzoic acid methyl ester

: 1401681-62-6
5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester

Guidance literature:: 1,2,3,4-tetrahydro-quinazoline-2,4-dione; With sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane; In toluene; for 5h; Reflux;

2-fluoro-5-bromomethyl benzoic acid methyl ester; In toluene; at 140 ℃; for 4h;

Reference yield:

: 2967-93-3
2-fluoro-5-methyl benzoic acid methyl ester

: 1401681-62-6
5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Inert atmosphere; Reflux

2.1: 1,1,1,3,3,3-hexamethyl-disilazane; sulfuric acid / toluene / 0.67 h / Reflux

2.2: 3 h / 140 °C

2.3: 0.5 h / 70 - 100 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrachloromethane; toluene;

Reference yield:

: 321-12-0
2-fluoro-5-methyl-benzoic acid

: 1401681-62-6
5-((2,4-dioxo-3,4-dihydroquinazolin-1(2Η)-yl)methyl)-2-fluorobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 3 h / Reflux

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetonitrile; tetrachloromethane / 1.5 h / Reflux

3.1: 1,1,1,3,3,3-hexamethyl-disilazane; sulfuric acid / toluene / 8 h / Inert atmosphere

3.2: 3 h / Inert atmosphere; Heating

3.3: 0.5 h / 70 - 100 °C / Inert atmosphere

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrachloromethane; toluene; acetonitrile;
DOI:10.1039/c8ob00286j