(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate

Base Information

Chemical Name:(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate
CAS No.:1539220-58-0
Molecular Formula:C₄₅H₅₁NO₃
Molecular Weight:653.905
Hs Code.:

Synonyms:(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate

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Chemical Property of (R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate

Chemical Property:

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Technology Process of (R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate

There total 13 articles about (R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1539221-44-7
(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenol

: 79-30-1
isobutyryl chloride

: 1539220-58-0
(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate

Guidance literature:: With pyridine; triethylamine; In dichloromethane; at 10 - 20 ℃; Concentration; Solvent; Time; Temperature;

Reference yield:

: 76-83-5
trityl chloride

: 1539220-58-0
(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine hydrochloride / N,N-dimethyl-formamide; pyridine / 4 h / 55 °C

2: triethylamine; pyridine / dichloromethane / 10 - 20 °C

With pyridine; pyridine hydrochloride; triethylamine; In pyridine; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 29922-56-3
2-bromo-4-(hydroxymethyl)phenol

: 1539220-58-0
(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate

Guidance literature:: Multi-step reaction with 6 steps

1: N-Methyldicyclohexylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 2-methyltetrahydrofuran / 70 - 86 °C

2: 5%-palladium/activated carbon; hydrogen; sodium carbonate / 2-methyltetrahydrofuran; ethanol / 50 °C / 750.08 Torr / Inert atmosphere

3: 5%-palladium/activated carbon; hydrogen; sodium carbonate / water; toluene / 50 - 55 °C / 750.08 Torr / Inert atmosphere

4: Vitride^? / toluene / 5 - 25 °C / Inert atmosphere; Cooling with ice

5: (S)-Mandelic acid / 2-methyltetrahydrofuran / 70 °C

6: triethylamine; pyridine / dichloromethane / 10 - 20 °C

With pyridine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-Methyldicyclohexylamine; 5%-palladium/activated carbon; (S)-Mandelic acid; hydrogen; sodium carbonate; triethylamine; In 2-methyltetrahydrofuran; ethanol; dichloromethane; water; toluene;