29922-56-3

Basic information

• Product Name: 2-BROMO-4-HYDROXYMETHYL-PHENOL
• Synonyms: 3-Bromo-4-hydroxybenzyl alcohol, (3-Bromo-4-hydroxyphenyl)methanol;RARECHEM AL BD 0697;3-BROMO-4-HYDROXYBENZYL ALCOHOL;2-BROMO-4-HYDROXYMETHYL-PHENOL;3-Bromo-4-hydroxybenzenemethanol;3-broMo-4-hydroxybenzylalchol
• CAS NO: 29922-56-3
• Molecular Formula: C₇H₇BrO₂
• Molecular Weight: 203.03
• EINECS: 249-957-8
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;pharmacetical
• Mol File: 29922-56-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 128-132℃
• Boiling Point: 307.8°Cat760mmHg
• Flash Point: 139.9°C
• Appearance: /
• Density: 1.722g/cm³
• Vapor Pressure: 0.000307mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: 2-8°C
• PKA: 8.21±0.18(Predicted)
• CAS DataBase Reference: 2-BROMO-4-HYDROXYMETHYL-PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-HYDROXYMETHYL-PHENOL(29922-56-3)
• EPA Substance Registry System: 2-BROMO-4-HYDROXYMETHYL-PHENOL(29922-56-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 29922-56-3(Hazardous Substances Data)

Usage

Chemical Properties

off-white crystalline

InChI:InChI=1/C7H7BrO2/c8-6-3-5(4-9)1-2-7(6)10/h1-3,9-10H,4H2

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 14348-41-5 3-bromo-4-hydroxy-benzoic acid 
• 6627-55-0 2-bromo-p-cresol 
• 107-21-1 ethylene glycol 
• 67-56-1 methanol 
• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 623-05-2 (4-hydroxyphenyl)methanol 

Downstream Products

• 1326774-95-1 (3S)-3-((tert-butyldimethylsilyl)oxy)-3,7-dimethyl-1-[2'-((2''-(trimethylsilyl)ethoxy)methoxy)-5'-(((2''-(trimethylsilyl)ethoxy)methoxy)methyl)phenyl]oct-6-en-1-ol 
• 1326774-96-2 (3S)-1-(2'-hydroxy-5'-(hydroxymethyl)phenyl)-3,7-dimethyloct-6-ene-1,3-diol 
• 1326774-97-3 (3'S)-4-hydroxy-3-(3'-hydroxy-3',7'-dimethyloct-6'-enoyl)benzaldehyde 
• 809281-21-8 (3'S)-4-hydroxy-3-(3'-hydroxy-3',7'-dimethyloct-6'-enoyl)benzoic acid 
• 1326775-04-5 (2-((2'-bromo-4'-(((2''-(trimethylsilyl)ethoxy)methoxy)methyl)phenoxy)methoxy)ethyl)trimethylsilane 
• 1276113-33-7 2-bromo-4-(((tert-butyldimethylsilyl)oxy)-methyl)phenol 
• 1539220-65-9 2-bromo-4-trityloxymethylphenol 
• 1539220-73-9 (E)-3-(2-hydroxy-5-(trityloxymethyl)phenyl)-N,N-diisopropyl-3-phenylacrylamide 
• 1539220-53-5 (R,S)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenol 
• 1539221-44-7 (R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenol 
• 1539221-45-8 (S)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenol 
• 1539262-89-9 (R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol hydrochloride 
• 1539220-58-0 (R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-trityloxymethylphenoxyisobutyrate 
• 286930-02-7 fesoterodine 

Relevant articles and documents

Synthesis of Benzothieno[60]fullerenes through Fullerenyl Cation Intermediates

Benzothieno[60]fullerenes were synthesized using fullerenyl cations as key intermediates. The reaction proceeded through a nucleophilic attack of the sulfur atom as a weak nucleophile to the fullerenyl cation electrophile. A monoarylated fullerene, (2-methylthiophenyl)hydro[60]fullerene, C60ArH (Ar = C6H4-SMe-2 and so on; four derivatives) was subjected to deprotonation with KOtBu to form a fullerenyl anion ArC60-, followed by oxidation using I2 to generate a fullerenyl cation ArC60+, leading to intramolecular demethylative cyclization via fullerene cation-S interaction to the product. Electrochemical and computational studies revealed slightly narrower band gap of this compound than usual fullerene derivatives because of the relatively high-lying HOMO of the fused thieno moiety.

A Quantitative Assay of Sodium Triacetoxyborohydride

Sodium triacetoxyborohydride (STAB) is a common reducing agent with potency that degrades over time and is not uniformly assigned. A simple assay based on an aldehyde reduction has been developed to determine the active borohydride content of this reagent. The HPLC assay yield of a salicylaldehyde reduction has been shown to accurately determine this potency and has been validated against the H2 evolution method as well as yields obtained from a reductive amination. The use of these assay data to adjust the STAB charge as well to optimize a reductive amination has been demonstrated.

The synthesis of 4,7-disubstituted-2H-benzo[b][1,4]-oxazin-3(4H)-ones using Smiles rearrangement and their in vitro evaluation as platelet aggregation inhibitors

A series of novel benzo[b][1,4]oxazin-3(4H)-one derivatives were synthesized as platelet aggregation inhibitors for structure-activity relationships (SAR) analysis. The synthetic pattern, involved Smiles rearrangement for the preparation of benzoxazine, was proven to be more efficient than the conventional methods. Biological evaluation demonstrated that among all the synthesized compounds, compound 9u (IC50 = 9.20 μM) exhibited the most potent inhibition activity compared with aspirin, the positive control (IC50 = 7.07 μM). Molecular docking revealed that these set of compounds could be the GPIIb/IIIa antagonist for that they could be situated in the binding site of GPIIb/IIIa receptor quite well.