Chemical Property of 3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine
Chemical Property:
- Appearance/Colour:yellow powder
- Vapor Pressure:1.33E-10mmHg at 25°C
- Melting Point:191-193 °C(lit.)
- Refractive Index:1.634
- Boiling Point:525.35 °C at 760 mmHg
- PKA:-0.06±0.63(Predicted)
- Flash Point:237.659 °C
- PSA：51.56000
- Density:1.202 g/cm3
- LogP:4.26760
- Storage Temp.:Inert atmosphere,Room Temperature
- Water Solubility.:Soluble in water.
- XLogP3:3.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:3
- Exact Mass:310.121846464
- Heavy Atom Count:24
- Complexity:376
- Purity/Quality:
-
99% *data from raw suppliers
3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1=CC=C(C=C1)C2=C(N=NC(=N2)C3=CC=CC=N3)C4=CC=CC=C4
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Uses
3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine was employed as chromogenic-extraction reagent during spectrophotometric determination of iron in acids and acidic solutions. It was also employed as precolumn derivatizing reagent in the HPLC method with UV absorbance detection for the Fe(II) determination.
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Indications
PDT with 20% ALA may be used for the treatment of actinic keratoses. The product is marketed as Levulan Kerastick (DUSA Pharmaceuticals, Valhalla, New York). The ALA is applied diffusely over the field with an applicator; the patient returns 1 to 3 hours later and is exposed to an activating light source. Once exposed to the light, ALA produces singlet oxygen, which damages the cell membrane. Sixty-six percent of patients had total clearing of lesions at 8 weeks using blue light exposure for 15 minutes. Patients experience a burning pain but heal with an excellent cosmetic result. Photosensitivity lasts for 24 hours. An optional regimen is to apply ALA only to visible actinic keratoses; however, this method will not treat subclinical lesions. A variety of lasers and light sources can be used to activate the ALA, including blue light, yellow light, and broadband light; however, many details remain to be worked out, such as the optimal incubation times for the ALA when using each of the various light sources.
