(+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

Base Information

Chemical Name:(+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]
CAS No.:949087-14-3
Molecular Formula:C₄₁H₅₂N₂O₇Si₂
Molecular Weight:741.044
Hs Code.:

Synonyms:(+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

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Chemical Property of (+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

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Technology Process of (+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

There total 7 articles about (+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 949087-11-0
(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanamide]

: 949087-12-1
(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

: 949087-14-3
(+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1016/j.tet.2007.05.109

Reference yield: 26.0%

: 949087-12-1
(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

: 949087-14-3
(+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

Guidance literature:: With formaldehyd; Amberlyst(R) 15; In water; acetone; for 24h; Heating;
DOI:10.1016/j.tet.2007.05.109

Reference yield:

: C₂₁H₂₇O₅Si^(1-)*Li⁽¹⁺⁾

: 949087-14-3
(+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; oxalyl chloride / diethyl ether / 14 h / 20 °C

2: 0.39 g / triethylamine; 4-dimethylaminopyridine / 18 h

3: 54 percent / trimethylsilylbromide / CH₂Cl₂ / 4 h / 0 °C

4: 26 percent / Amberlyst(R) 15; paraformaldehyde / acetone; H₂O / 24 h / Heating

With pyridine; dmap; formaldehyd; oxalyl dichloride; trimethylsilyl bromide; Amberlyst(R) 15; triethylamine; In diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/j.tet.2007.05.109