(+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate

Base Information

• Chemical Name: (+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate
• CAS No.: 949087-09-6
• Molecular Formula: C₂₂H₃₀O₅Si
• Molecular Weight: 402.563

Synonyms:(+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate

Chemical Property of (+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate

Chemical Property:

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Technology Process of (+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate

There total 2 articles about (+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(-)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-hyrdoxypropanoate (142564-20-3) + ethyl chloromethyl ether (3188-13-4) → (+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate (949087-09-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.3998/ark.5550190.0011.910

Reference yield: 84.0%

chloromethyl methyl ether (107-30-2) + (-)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-hyrdoxypropanoate (142564-20-3) → (+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate (949087-09-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1016/j.tet.2007.05.109

Reference yield: 88.0%

(+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate (949087-09-6) → (2S)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanol (1231671-97-8)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.3998/ark.5550190.0011.910

upstream raw materials:

chloromethyl methyl ether

(-)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-hyrdoxypropanoate

ethyl chloromethyl ether

Downstream raw materials:

(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoyl chloride

(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanamide]

(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

(+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

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