(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

Base Information

Chemical Name:(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]
CAS No.:949087-12-1
Molecular Formula:C₄₈H₅₉N₃O₇Si₂
Molecular Weight:846.183
Hs Code.:

Synonyms:(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

Chemical Property:

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Technology Process of (+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

There total 9 articles about (+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 949087-11-0
(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanamide]

: 949087-12-1
(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

: 949087-14-3
(+)-N,N'-(2-oxopropane-1,3-diyl)bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1016/j.tet.2007.05.109

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 949087-12-1
(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

Guidance literature:: Multi-step reaction with 5 steps

1: 2.32 g / ethanol / 24 h / 20 °C

2: 84 percent / dimethylformamide / 100 °C

3: hydrazine hydrate / methanol / 3 h / Heating

4: 0.39 g / triethylamine; 4-dimethylaminopyridine / 18 h

5: 54 percent / trimethylsilylbromide / CH₂Cl₂ / 4 h / 0 °C

With dmap; trimethylsilyl bromide; hydrazine hydrate; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.05.109

Reference yield:

: 949087-09-6
(+)-methyl-(2R)-3-(tert-butyldiphenylsilyloxy)-2-(methoxymethoxy)propanoate

: 949087-12-1
(+)-N,N'-{2-[(benzyloxy)imino]propane-1,3-diyl}-bis[(2R)-3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanamide]

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C

2: pyridine; oxalyl chloride / diethyl ether / 14 h / 20 °C

3: 0.39 g / triethylamine; 4-dimethylaminopyridine / 18 h

4: 54 percent / trimethylsilylbromide / CH₂Cl₂ / 4 h / 0 °C

With pyridine; dmap; lithium hydroxide; oxalyl dichloride; trimethylsilyl bromide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2007.05.109