2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)acetic acid

Base Information

Chemical Name:2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)acetic acid
CAS No.:1187857-82-4
Molecular Formula:C₂₅H₂₉ClN₂O₆
Molecular Weight:488.968
Hs Code.:

Synonyms:2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)acetic acid

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Chemical Property of 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)acetic acid

Chemical Property:

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Technology Process of 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)acetic acid

There total 10 articles about 2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187857-81-3
2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid chloride

: 56-40-6,18875-39-3,25718-94-9
glycine

: 1187857-82-4
2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)acetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; Heating;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1187857-82-4
2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium t-butanolate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 1.5 h / Inert atmosphere; Reflux

2: potassium phosphate / acetonitrile / 8 h / 65 °C / Inert atmosphere

3: acetonitrile / 65 °C / Inert atmosphere

4: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 3 - 50 °C

5: hydrogenchloride; water / pH 3

6: thionyl chloride / Reflux

7: sodium hydroxide / tetrahydrofuran; water / 20 °C / Heating

With hydrogenchloride; potassium phosphate; thionyl chloride; tetrabutylammomium bromide; water; sodium hydroxide; sodium t-butanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; toluene; acetonitrile;

Reference yield:

: 1187856-44-5
(4-chlorophenyl)(phenyl)carbamic chloride

: 1187857-82-4
2-(2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / Reflux

2: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 3 - 50 °C

3: hydrogenchloride; water / pH 3

4: thionyl chloride / Reflux

5: sodium hydroxide / tetrahydrofuran; water / 20 °C / Heating

With pyridine; hydrogenchloride; thionyl chloride; tetrabutylammomium bromide; water; sodium hydroxide; In tetrahydrofuran; water; toluene;