N-4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N-2-(3-(3-chloropropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Base Information

Chemical Name:N-4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N-2-(3-(3-chloropropylsulfonyl)phenyl)pyrimidine-2,4-diamine
CAS No.:1421918-02-6
Molecular Formula:C₂₀H₁₈Cl₂N₄O₄S
Molecular Weight:481.359
Hs Code.:

Synonyms:N-4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N-2-(3-(3-chloropropylsulfonyl)phenyl)pyrimidine-2,4-diamine

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Chemical Property of N-4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N-2-(3-(3-chloropropylsulfonyl)phenyl)pyrimidine-2,4-diamine

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Technology Process of N-4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N-2-(3-(3-chloropropylsulfonyl)phenyl)pyrimidine-2,4-diamine

There total 4 articles about N-4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N-2-(3-(3-chloropropylsulfonyl)phenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 945396-72-5
2-chloro-N-(5-chlorobenzo[d][1,3]dioxol-4-yl)pyrimidin-4-amine

: 1421917-99-8
3-(3-chloropropylsulfonyl)aniline

: 1421918-02-6
N-4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N-2-(3-(3-chloropropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 48h;
DOI:10.1002/cmdc.201200264

Reference yield:

: 25062-90-2
3-phenylsulfonylpropanol

: 1421918-02-6
N-4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N-2-(3-(3-chloropropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; tetrachloromethane / chloroform / 48 h / 20 °C

2: potassium nitrate; sulfuric acid / 6 h / 70 °C

3: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C / 1125.11 - 1500.15 Torr

4: toluene-4-sulfonic acid / 1,4-dioxane / 48 h / 100 °C

With tetrachloromethane; sulfuric acid; palladium on activated charcoal; hydrogen; toluene-4-sulfonic acid; potassium nitrate; triphenylphosphine; In 1,4-dioxane; methanol; chloroform; 1: |Appel Halogenation;
DOI:10.1002/cmdc.201200264

Reference yield:

: 873-55-2
sodium benzenesulfonate

: 1421918-02-6
N-4-(5-chlorobenzo[d][1,3]dioxol-4-yl)-N-2-(3-(3-chloropropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutylammomium bromide; sodium iodide / water; chloroform / 16 h / Reflux

2: triphenylphosphine; tetrachloromethane / chloroform / 48 h / 20 °C

3: potassium nitrate; sulfuric acid / 6 h / 70 °C

4: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C / 1125.11 - 1500.15 Torr

5: toluene-4-sulfonic acid / 1,4-dioxane / 48 h / 100 °C

With tetrachloromethane; sulfuric acid; palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; toluene-4-sulfonic acid; potassium nitrate; triphenylphosphine; sodium iodide; In 1,4-dioxane; methanol; chloroform; water; 2: |Appel Halogenation;
DOI:10.1002/cmdc.201200264