(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate

Base Information

Chemical Name:(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate
CAS No.:948842-80-6
Molecular Formula:C₃₈H₄₁N₆O₈P
Molecular Weight:740.753
Hs Code.:

(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate

Synonyms:(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate

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Chemical Property of (bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate

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Technology Process of (bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate

There total 7 articles about (bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 623155-48-6
4-chloro-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide

: 948842-78-2
(bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate

: 948842-80-6
(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate

Guidance literature:: In N,N-dimethyl-formamide;

Reference yield:

: 948842-74-8
iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

: 948842-80-6
(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / Reflux

2: zinc; ammonium chloride / tetrahydrofuran; methanol / 20 °C

3: N,N-dimethyl-formamide / 20 °C

With ammonium chloride; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2013.03.022

Reference yield:

: 948842-72-6
chloromethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

: 948842-80-6
(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / acetone / Reflux

2: toluene / Reflux

3: zinc; ammonium chloride / tetrahydrofuran; methanol / 20 °C

4: N,N-dimethyl-formamide / 20 °C

With ammonium chloride; sodium iodide; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.bmcl.2013.03.022