(bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate

Base Information

• Chemical Name: (bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate
• CAS No.: 948842-78-2
• Molecular Formula: C₂₇H₂₉N₂O₇P
• Molecular Weight: 524.51
• Mol file: 948842-78-2.mol

Synonyms:(bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate

Chemical Property of (bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate

There total 4 articles about (bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-nitrobenzoyl)carbamate (948842-76-0) → (bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate (948842-78-2)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; methanol; for 3h;

Reference yield:

iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate (948842-74-8) → (bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate (948842-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Reflux

2: zinc; ammonium chloride / tetrahydrofuran; methanol / 20 °C

With ammonium chloride; zinc; In tetrahydrofuran; methanol; toluene;

DOI:10.1016/j.bmcl.2013.03.022

Reference yield:

N-cyclopropyl-4-methyl-3-nitrobenzamide (303133-89-3) → (bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate (948842-78-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: 0 - 20 °C

2.1: sodium iodide / acetone / Reflux

3.1: toluene / Reflux

4.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 20 °C

With ammonium chloride; sodium iodide; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; acetone; toluene;

DOI:10.1016/j.bmcl.2013.03.022

upstream raw materials:

(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

N-cyclopropyl-4-methyl-3-nitrobenzamide

chloromethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

Downstream raw materials:

(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate