methyl (S)-(4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl)carbamate

Base Information

Chemical Name:methyl (S)-(4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl)carbamate
CAS No.:1370248-33-1
Molecular Formula:C₃₃H₃₃N₃O₆
Molecular Weight:567.642
Hs Code.:

Synonyms:methyl (S)-(4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl)carbamate

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Chemical Property of methyl (S)-(4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl)carbamate

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Technology Process of methyl (S)-(4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl)carbamate

There total 1 articles about methyl (S)-(4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 67-56-1
methanol

: 1370248-13-7
(S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid

: 1370248-33-1
methyl (S)-(4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl)carbamate

Guidance literature:: (S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid; With chloroformic acid ethyl ester; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Cooling with ice;

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Cooling with ice;

methanol; at 50 ℃; for 3h;
DOI:10.1021/acs.jmedchem.9b00861

Reference yield: 100.0%

: 1370248-33-1
methyl (S)-(4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl)carbamate

: 1370248-34-2
(S)-7-amino-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Guidance literature:: With sodium hydroxide; In ethanol; water; at 60 ℃; for 2h;
DOI:10.1021/acs.jmedchem.9b00861

Reference yield:

: 1370248-33-1
methyl (S)-(4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl)carbamate

: 1370237-86-7
(S)-7-amino-4-benzhydryl-9-hydroxy-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 2 h / 60 °C

2: trifluoroacetic acid / 1 h / 20 °C

With water; trifluoroacetic acid; sodium hydroxide; In ethanol;