(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl methanesulfonate

Base Information

Chemical Name:(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl methanesulfonate
CAS No.:856687-73-5
Molecular Formula:C₂₈H₄₄O₆SSi
Molecular Weight:536.805
Hs Code.:

Synonyms:(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl methanesulfonate

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Chemical Property of (2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl methanesulfonate

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Technology Process of (2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl methanesulfonate

There total 5 articles about (2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 856687-71-3
(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenyl-1-pentanol

: 124-63-0
methanesulfonyl chloride

: 856687-73-5
(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl methanesulfonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1011-27-4
3,5-dimethoxy-4-methylbenzaldehyde

: 856687-73-5
(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; chloro-trimethyl-silane; magnesium chloride / ethyl acetate / 20 °C

1.2: 0.08 h

2.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 °C

3.1: lithium borohydride / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.25 h / 0 - 20 °C

With 2,6-dimethylpyridine; lithium borohydride; chloro-trimethyl-silane; triethylamine; magnesium chloride; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/acsmedchemlett.7b00383

Reference yield:

: 161725-13-9
(4S)-4-benzyl-3-(5-phenylpentanoyl)-1,3-oxazolidin-2-one

: 856687-73-5
(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl){[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl]-5-phenylpentyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; chloro-trimethyl-silane; magnesium chloride / ethyl acetate / 20 °C

1.2: 0.08 h

2.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 °C

3.1: lithium borohydride / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.25 h / 0 - 20 °C

With 2,6-dimethylpyridine; lithium borohydride; chloro-trimethyl-silane; triethylamine; magnesium chloride; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/acsmedchemlett.7b00383