(S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one

Base Information

Chemical Name:(S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one
CAS No.:1236003-60-3
Molecular Formula:C₂₂H₂₅NO₂
Molecular Weight:335.446
Hs Code.:

Synonyms:(S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one

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Technology Process of (S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one

There total 2 articles about (S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 556-56-9
allyl iodid

: 173602-37-4
(S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-benzylisoxazolidin-5-one

: 1236003-60-3
(S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one

: (3S,4R,αS)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one

Guidance literature:: (S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-benzylisoxazolidin-5-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

allyl iodid; In tetrahydrofuran; at -78 - 20 ℃; for 16h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.04.027

Reference yield: 47.0%

: (3S,αS)-N(2)-α-methylbenzyl-3-methyl-4-allylisoxazolidin-5-one

: 100-39-0
benzyl bromide

: 1236003-60-3
(S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one

: (3S,4R,αS)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one

Guidance literature:: (3S,αS)-N(2)-α-methylbenzyl-3-methyl-4-allylisoxazolidin-5-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; for 16h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.04.027

Reference yield: 86.0%

: 1236003-60-3
(S,S,S)-N(2)-α-methylbenzyl-3-methyl-4-allyl-4-benzylisoxazolidin-5-one

: 1236003-71-6
(S,S)-2-benzyl-2-propyl-3-aminobutanoic acid

Guidance literature:: With Pearlman's catalist; hydrogen; In tert-butyl alcohol; at 70 ℃; for 20h; under 760.051 Torr;
DOI:10.1016/j.tet.2010.04.027