Technology Process of N-[5-benzyl-1,3-thiazol-2-yl]chromane-3-carboxamide
There total 3 articles about N-[5-benzyl-1,3-thiazol-2-yl]chromane-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,4-dihydro-2H-1-benzopyran-3-carboxylic acid;
With
1,1'-carbonylbis(3-methyl-1H-imidazol-3-ium) triflate;
In
1,4-dioxane; nitromethane;
at 40 ℃;
for 0.333333h;
Inert atmosphere;
5-(phenylmethyl)-1,3-thiazol-2-amine;
In
1,4-dioxane; nitromethane;
at 70 ℃;
for 2h;
Microwave irradiation;
Inert atmosphere;
DOI:10.1002/ardp.200800201
- Guidance literature:
-
Multi-step reaction with 3 steps
1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
2: triethylsilane; trifluoroacetic acid / dichloromethane / 20 °C
3: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
With
triethylsilane; dmap; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.12.006
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylsilane; trifluoroacetic acid / dichloromethane / 20 °C
2: triethylamine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
With
triethylsilane; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.12.006
