121952-97-4

Usage

Uses

Used in Pharmaceutical Industry:
5-Benzyl-1,3-thiazol-2-amine is used as a building block for the synthesis of various pharmaceutical drugs and organic compounds. Its unique structure and potential biological activities make it a valuable component in the development of new medications.
Used in Research:
In the research field, 5-Benzyl-1,3-thiazol-2-amine is utilized for studying its anti-inflammatory and anti-cancer properties. Its potential to modulate biological processes and target specific pathways makes it a subject of interest for scientific investigations.
Used in Materials Science:
5-Benzyl-1,3-thiazol-2-amine may also have applications in the field of materials science, where its unique chemical properties could contribute to the development of new materials with specific characteristics.
Used as a Ligand in Coordination Chemistry:
In coordination chemistry, 5-Benzyl-1,3-thiazol-2-amine serves as a ligand, interacting with metal ions to form coordination compounds. This role is crucial for the study and development of new coordination complexes with potential applications in various fields, such as catalysis, sensing, and medicinal chemistry.

InChI:InChI=1/C10H10N2S/c11-10-12-7-9(13-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H2,11,12)

Upstream product

• 100-34-5 benzene diazonium chloride 
• 104-53-0 3-phenyl-propionaldehyde 
• 17356-08-0 thiourea 
• 51075-28-6 2-bromo-3-phenylpropanal 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 19261-37-1 2-chloro-3-phenyl-propionaldehyde 
• 62-56-6 thiourea 

Downstream Products

• 144836-50-0 ethyl 2-benzyl-6-phenylimidazo<2.1-b>thiazole-5-carboxylate 
• 919018-15-8 N-[5-benzyl-1,3-thiazol-2-yl]chromane-3-carboxamide 
• 301157-23-3 C₁₅H₁₂N₂O₂S 
• 1235559-89-3 N-(5-benzylthiazol-2-yl)decanamide 
• 1061161-52-1 N-(5-benzylthiazol-2-yl)-3-(furan-2-yl)propanamide 
• 267654-15-9 N-(5-benzylthiazol-2-yl)butyramide 
• 851722-11-7 C₁₃H₁₃ClN₂OS 
• 1353638-23-9 C₁₃H₁₁N₃OS₂ 
• 301306-13-8 N-(5-Benzyl-thiazol-2-yl)-2-chloro-acetamide 
• 923679-02-1 N-(5-benzyl-1,3-thiazol-2-yl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 871323-56-7 N-(5-benzyl-1,3-thiazol-2-yl)-1-(2-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide 
• 144836-54-4 N-(5-benzylthiazol-2-yl)benzamide 

Relevant academic research and scientific papers

Proapoptotic effects of novel thiazole derivative on human glioma cells

The aim of the present study was to investigate the antiproliferative and proapoptotic actions of N-(5-benzyl-1,3-thiazol-2-yl)-3,5-dimethyl-1-benzofuran-2-carboxamide derivative (compound 5) in glioma cells in comparison with the actions of temozolomide

1-[(5-Benzyl-1,3-thiazol-2-yl)diazenyl]naphthalene-2-ol: X-ray structure, spectroscopic characterization, dissociation studies and application in mercury(II) detection

A new thiazolylazo reagent, 1-[(5-benzyl-1,3-thiazol-2-yl)diazenyl]naphthalene-2-ol, has been synthesized for the first time. Single crystals of the azo dye were grown from a saturated solution by the vapour diffusion technique. The compound was analyzed

Synthesis, structural characterization and thermal studies of a novel reagent 1-[(5-benzyl-1,3-thiazol-2-yl)diazenyl]naphthalene-2-ol

A new thiazolylazo reagent 1-[(5-benzyl-1,3-thiazol-2-yl)diazenyl]naphthalene-2-ol has been synthesized via arylation of acrolein and further diazotization and diazocoupling with 2-naphthol. The chemical structure of the compound was confirmed by IR, NMR:

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Synthesis and antitumor activities of new n-(5-benzylthiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides

Aim. Synthesis of a series of new N-(5-benzyl-thiazol-2-yl)-2-(heteryl-5-ylsulfanyl)-acetamides and study of their anticancer activity. Methods. Organic synthesis, analytical and spectral methods, pharmacological screening. Results. [2-chloro-N-(5-aryl-1,

Antineoplastic activity of novel thiazole derivatives

The development of novel efficient substances for anticancer chemotherapy is an important problem of medicinal chemistry. Aim. To evaluate the level of cytotoxic action of novel thiazole derivatives towards tumor cell lines of different origin. Methods. F

Identification of KPNB1 as a Cellular Target of Aminothiazole Derivatives with Anticancer Activity

We found that aminothiazole derivative (E)-N-(5-benzylthiazol-2-yl)-3-(furan-2-yl)acrylamide (1) has strong anticancer activity, and undertook proteomics approaches to identify the target protein of compound 1, importin β1 (KPNB1). A competitive binding assay using fluorescein-labeled 1 showed that 1 has strong binding affinity for KPNB1 (Kd: ～20 nm). Furthermore, through western blotting assays for KPNB1, KPNA2, EGFR, ErbB2, and STAT3, we confirmed that 1 has inhibitory effects on the importin pathway. KPBN1 appears to be overexpressed in several cancer cells, and siRNA-induced inhibition of KPNB1 shows significant inhibition of cancer cell proliferation, while leaving non-cancerous cells unaffected. Therefore, compound 1 is a promising new lead for the development of KPNB1-targeted anticancer agents. Fluorescein-labeled 1 could be a useful quantitative probe for the development of novel KPNB1 inhibitors.

Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors

Src family kinases (SFKs) are a family of non-receptor tyrosine kinases (TKs) implicated in the regulation of many cellular processes. The aberrant activity of these TKs has been associated with the growth and progression of cancer. In particular, c-Src i