1,1-dimethylethyl (2S)-2-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2S)-2-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate
CAS No.:1244740-14-4
Molecular Formula:C₁₇H₂₅N₃O₃
Molecular Weight:319.404
Hs Code.:

Synonyms:1,1-dimethylethyl (2S)-2-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

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Chemical Property of 1,1-dimethylethyl (2S)-2-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

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Technology Process of 1,1-dimethylethyl (2S)-2-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

There total 1 articles about 1,1-dimethylethyl (2S)-2-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 103-71-9
phenyl isocyanate

: 169447-70-5
(S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 1244740-14-4
1,1-dimethylethyl (2S)-2-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

Guidance literature:: phenyl isocyanate; (S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester; With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water;

Reference yield: 74.0%

: 1244740-14-4
1,1-dimethylethyl (2S)-2-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

: 1244740-15-5
(3S)-3-methyI-N-phenyl-1-piperazinecarboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1244740-14-4
1,1-dimethylethyl (2S)-2-methyl-4-[(phenylamino)carbonyl]-1-piperazinecarboxylate

: (S)-3-methyl-4-(3-(3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)propanoyl)-N-phenylpiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0 °C

2: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / dimethyl sulfoxide / 20 °C

With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/cmdc.201800739