7-allyl-2-methyl-4-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-[1,4]oxazepine

Base Information

Chemical Name:7-allyl-2-methyl-4-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-[1,4]oxazepine
CAS No.:1378523-74-0
Molecular Formula:C₁₆H₂₁NO₃S
Molecular Weight:307.414
Hs Code.:

Synonyms:7-allyl-2-methyl-4-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-[1,4]oxazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-allyl-2-methyl-4-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-[1,4]oxazepine

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Technology Process of 7-allyl-2-methyl-4-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-[1,4]oxazepine

There total 5 articles about 7-allyl-2-methyl-4-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-[1,4]oxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1378524-24-3
N-(3-hydroxyhex-5-enyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide

: 1378523-74-0
7-allyl-2-methyl-4-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-[1,4]oxazepine

Guidance literature:: With sodium hydride; at 70 ℃; for 0.666667h; regioselective reaction; Neat (no solvent);
DOI:10.1021/ol301219c

Reference yield:

: 187887-01-0
N-(3-hydroxypropyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide

: 1378523-74-0
7-allyl-2-methyl-4-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-[1,4]oxazepine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 6 h / 10 - 28 °C

2: tetrahydrofuran / 0.92 h / 5 - 28 °C

3: sodium hydride / 0.67 h / 70 °C / Neat (no solvent)

With sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol301219c

Reference yield:

: 42908-33-8
3-{[(4-methylphenyl)sulfonyl]amino}propanoic acid

: 1378523-74-0
7-allyl-2-methyl-4-(toluene-4-sulfonyl)-4,5,6,7-tetrahydro-[1,4]oxazepine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 4 h / 60 - 70 °C

2: lithium borohydride / tetrahydrofuran; ethanol / 1 h / 5 - 28 °C

3: pyridinium chlorochromate / dichloromethane / 6 h / 10 - 28 °C

4: tetrahydrofuran / 0.92 h / 5 - 28 °C

5: sodium hydride / 0.67 h / 70 °C / Neat (no solvent)

With lithium borohydride; sodium hydride; potassium carbonate; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ol301219c