methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate

Base Information

Chemical Name:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate
CAS No.:1445789-88-7
Molecular Formula:C₃₂H₃₅N₅O₅
Molecular Weight:569.66
Hs Code.:

Synonyms:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate

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Chemical Property of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate

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Technology Process of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate

There total 13 articles about methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

: 936250-17-8
2,4‐dimethoxy‐5‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)pyrimidine

: 1445789-86-5
methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate

: 1445789-88-7
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 6h; Inert atmosphere;

Reference yield:

: 1445790-46-4
methyl 3-amino-5-cyclopentylbenzoate

: 1445789-88-7
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 6 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; ethanol; water;

Reference yield:

: 6307-87-5
methyl 3-bromo-5-nitrobenzoate

: 1445789-88-7
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 12 h / 50 °C

3: ethanol / Reflux

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 6 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;