methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate

Base Information

Chemical Name:methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate
CAS No.:1445789-86-5
Molecular Formula:C₂₆H₂₈BrN₃O₃
Molecular Weight:510.431
Hs Code.:

Synonyms:methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate

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Chemical Property of methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate

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Technology Process of methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate

There total 10 articles about methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6307-87-5
methyl 3-bromo-5-nitrobenzoate

: 1445789-86-5
methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: hydrogen; acetic acid; palladium 10% on activated carbon / methanol / 12 h / 50 °C

3: ethanol / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 101980-41-0
2-bromo-1-isopropyl-4-nitrobenzene

: 1445789-86-5
methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: iron; acetic acid / methanol / 4 h / 20 °C

2: ethanol / 2 h / Reflux

3: diphenylether / 0.25 h / Reflux

4: sodium hydroxide; water / ethanol / 4 h / Reflux

5: trichlorophosphate / 4 h / Reflux

6: ammonium hydroxide / tetrahydrofuran / 0.5 h / 0 °C

7: ethanol / Reflux

With ammonium hydroxide; water; iron; acetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; diphenylether; ethanol;

Reference yield:

: 1445789-78-5
diethyl 2-((3-bromo-4-isopropylphenylamino)methylene)malonate

: 1445789-86-5
methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: diphenylether / 0.25 h / Reflux

2: sodium hydroxide; water / ethanol / 4 h / Reflux

3: trichlorophosphate / 4 h / Reflux

4: ammonium hydroxide / tetrahydrofuran / 0.5 h / 0 °C

5: ethanol / Reflux

With ammonium hydroxide; water; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; diphenylether; ethanol;