3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester
CAS No.:870456-21-6
Molecular Formula:C₃₀H₄₀N₂O₇
Molecular Weight:540.657
Hs Code.:

3-(2-<i>tert</i>-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester

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Chemical Property of 3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester

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Technology Process of 3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester

There total 11 articles about 3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 303068-07-7
4-(3-allyl-2-methoxyphenyl)-N,N'-di-tert-butoxycarbonyltryptamine

: 870456-21-6
3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With osmium (III) chloride; potassium carbonate; potassium hexacyanoferrate(III); Quinuclidine; In tert-butyl alcohol; for 48h;
DOI:10.1039/b510653b

Reference yield:

: 303068-04-4
4-bromo-3-(2-nitroethenyl)-indole

: 870456-21-6
3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 20 °C

2: 2.10 g / DMAP / acetonitrile / 20 °C

3: 85 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / Heating

4: 84 percent / OsCl₃; K₃Fe(CN)6; aq. K₂CO₃ / quinuclidine / 2-methyl-propan-2-ol / 48 h

With dmap; lithium aluminium tetrahydride; osmium (III) chloride; sodium carbonate; potassium carbonate; potassium hexacyanoferrate(III); Quinuclidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; acetonitrile; tert-butyl alcohol; 3: Suzuki coupling;
DOI:10.1039/b510653b

Reference yield:

: C₁₂H₁₇BO₃

: 870456-21-6
3-(2-tert-butoxycarbonylamino-ethyl)-4-[3-(2,3-dihydroxy-propyl)-2-methoxy-phenyl]-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 0.6 g / aq. HCl

2: 85 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / Heating

3: 84 percent / OsCl₃; K₃Fe(CN)6; aq. K₂CO₃ / quinuclidine / 2-methyl-propan-2-ol / 48 h

With hydrogenchloride; osmium (III) chloride; sodium carbonate; potassium carbonate; potassium hexacyanoferrate(III); Quinuclidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1039/b510653b