Technology Process of ethyl 4-{3-[1-tert-butoxycarbonyl-3-(2-tert-butoxycarbonylaminoethyl)indol-4-yl]-2-methoxyphenyl}-3-oxobutanoate
There total 15 articles about ethyl 4-{3-[1-tert-butoxycarbonyl-3-(2-tert-butoxycarbonylaminoethyl)indol-4-yl]-2-methoxyphenyl}-3-oxobutanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tin(ll) chloride;
In
dichloromethane;
at 20 ℃;
DOI:10.1039/b510653b
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 85 percent / K2CO3 / acetone / Heating
2.1: t-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C
2.2: hexane; tetrahydrofuran / 1 h / 20 °C
3.1: 0.6 g / aq. HCl
4.1: 85 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane / Heating
5.1: 84 percent / OsCl3; K3Fe(CN)6; aq. K2CO3 / quinuclidine / 2-methyl-propan-2-ol / 48 h
6.1: 99 percent / aq. NaIO4 / tetrahydrofuran / 2.5 h / 20 °C
7.1: 99 percent / SnCl2 / CH2Cl2 / 20 °C
With
hydrogenchloride; sodium periodate; osmium (III) chloride; tert.-butyl lithium; sodium carbonate; potassium carbonate; tin(ll) chloride; potassium hexacyanoferrate(III);
Quinuclidine; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; acetone; tert-butyl alcohol;
4.1: Suzuki coupling;
DOI:10.1039/b510653b
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 100 percent / Et2AlCl / hexane / 2.5 h / 20 °C
2.1: 85 percent / K2CO3 / acetone / Heating
3.1: t-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C
3.2: hexane; tetrahydrofuran / 1 h / 20 °C
4.1: 0.6 g / aq. HCl
5.1: 85 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane / Heating
6.1: 84 percent / OsCl3; K3Fe(CN)6; aq. K2CO3 / quinuclidine / 2-methyl-propan-2-ol / 48 h
7.1: 99 percent / aq. NaIO4 / tetrahydrofuran / 2.5 h / 20 °C
8.1: 99 percent / SnCl2 / CH2Cl2 / 20 °C
With
hydrogenchloride; sodium periodate; osmium (III) chloride; tert.-butyl lithium; diethylaluminium chloride; sodium carbonate; potassium carbonate; tin(ll) chloride; potassium hexacyanoferrate(III);
Quinuclidine; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; acetone; tert-butyl alcohol;
1.1: Claisen rearrangement / 5.1: Suzuki coupling;
DOI:10.1039/b510653b
