Technology Process of ethyl 2-(5-fluoro-2-nitrophenyl)-3-oxobutanoate
There total 1 articles about ethyl 2-(5-fluoro-2-nitrophenyl)-3-oxobutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl acetoacetate;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
Large scale reaction;
2,4-Difluoronitrobenzene;
In
tetrahydrofuran;
at 20 ℃;
Large scale reaction;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 10 ℃;
pH=4 - 5;
Large scale reaction;
DOI:10.1007/s11164-010-0210-x
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulfuric acid; acetic acid / 30 - 70 °C / Large scale reaction
2: methanol / 30 - 35 °C / Large scale reaction
3: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction
4: boron tribromide / dichloromethane / -8 - 0 °C
With
sodium dithionite; sulfuric acid; boron tribromide; acetic acid;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1007/s11164-010-0210-x
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid; acetic acid / 30 - 70 °C / Large scale reaction
2: methanol / 30 - 35 °C / Large scale reaction
3: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction
With
sodium dithionite; sulfuric acid; acetic acid;
In
tetrahydrofuran; methanol; water;
DOI:10.1007/s11164-010-0210-x
