10-acetyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

Base Information

Chemical Name:10-acetyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel
CAS No.:485801-36-3
Molecular Formula:C₅₈H₉₁NO₁₅Si₂
Molecular Weight:1098.53
Hs Code.:

Synonyms:10-acetyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 10-acetyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

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Technology Process of 10-acetyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

There total 8 articles about 10-acetyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 115437-21-3
7-(triethylsilyl)baccatin III

: 178250-11-8
(3R,4S)-1-tert-butoxycarbonyl-3-triisopropylsilyloxy-4-(2-methylprop-1-enyl)azetidin-2-one

: 485801-36-3
10-acetyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 ℃; for 0.5h;
DOI:10.1021/jm800086e

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 485801-36-3
10-acetyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole / dimethylformamide

2: lithium hexamethyldisilazide / tetrahydrofuran / -40 - 0 °C

3: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -30 °C

With 1H-imidazole; sodium hexamethyldisilazane; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00181-0

Reference yield:

: 994-30-9
triethylsilyl chloride

: 485801-36-3
10-acetyl-3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole / dimethylformamide

2: lithium hexamethyldisilazide / tetrahydrofuran / -40 - 0 °C

3: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -30 °C

With 1H-imidazole; sodium hexamethyldisilazane; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00181-0