3'-dephenyl-3'-(2-methylprop-1-enyl)-10-(3-methyldisulfanylpropanoyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

Base Information

Chemical Name:3'-dephenyl-3'-(2-methylprop-1-enyl)-10-(3-methyldisulfanylpropanoyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel
CAS No.:485801-38-5
Molecular Formula:C₆₀H₉₅NO₁₅S₂Si₂
Molecular Weight:1190.71
Hs Code.:

Synonyms:3'-dephenyl-3'-(2-methylprop-1-enyl)-10-(3-methyldisulfanylpropanoyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

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Chemical Property of 3'-dephenyl-3'-(2-methylprop-1-enyl)-10-(3-methyldisulfanylpropanoyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

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Technology Process of 3'-dephenyl-3'-(2-methylprop-1-enyl)-10-(3-methyldisulfanylpropanoyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

There total 4 articles about 3'-dephenyl-3'-(2-methylprop-1-enyl)-10-(3-methyldisulfanylpropanoyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 138148-59-1
3-Methyldisulfanyl-propionic acid

: 485801-37-4
3'-dephenyl-3'-(2-methylprop-1-enyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

: 485801-38-5
3'-dephenyl-3'-(2-methylprop-1-enyl)-10-(3-methyldisulfanylpropanoyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

Guidance literature:: With diisopropyl-carbodiimide; dmap; In dichloromethane;
DOI:10.1021/jm025540g

Reference yield:

: 115437-21-3
7-(triethylsilyl)baccatin III

: 485801-38-5
3'-dephenyl-3'-(2-methylprop-1-enyl)-10-(3-methyldisulfanylpropanoyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / lithium hexamethyldisilazide / tetrahydrofuran / 0.67 h / -40 °C

2: 87 percent / hydrazine monohydrate / ethanol

3: 80 percent / 1,3-diisopropylcarbodiimide / DMAP / CH₂Cl₂

With hydrazine hydrate; lithium hexamethyldisilazane; diisopropyl-carbodiimide; dmap; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm025540g

Reference yield:

: 178250-11-8
(3R,4S)-1-tert-butoxycarbonyl-3-triisopropylsilyloxy-4-(2-methylprop-1-enyl)azetidin-2-one

: 485801-38-5
3'-dephenyl-3'-(2-methylprop-1-enyl)-10-(3-methyldisulfanylpropanoyl)-7-triethylsilyl-2'-triisopropylsilyldocetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / lithium hexamethyldisilazide / tetrahydrofuran / 0.67 h / -40 °C

2: 87 percent / hydrazine monohydrate / ethanol

3: 80 percent / 1,3-diisopropylcarbodiimide / DMAP / CH₂Cl₂

With hydrazine hydrate; lithium hexamethyldisilazane; diisopropyl-carbodiimide; dmap; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm025540g