alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol

Base Information

Chemical Name:alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol
CAS No.:101910-24-1
Molecular Formula:C22H25NO2
Molecular Weight:335.446
Hs Code.:
European Community (EC) Number:634-425-3
UNII:WNW5RYD8MG
DSSTox Substance ID:DTXSID00906795
Nikkaji Number:J291.659B
Wikidata:Q27163617
Pharos Ligand ID:UBXH4TPP18G7
ChEMBL ID:CHEMBL8747
Mol file:101910-24-1.mol

Synonyms:alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol;PF 5901;PF-5901;REV 5901;REV-5901;RG 5901;RG-5901

Suppliers and Price of alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
L-655,238
25mg
$ 145.00

Cayman Chemical
REV 5901 ≥98%
50mg
$ 200.00

Cayman Chemical
REV 5901 ≥98%
100mg
$ 350.00

Cayman Chemical
REV 5901 ≥98%
10mg
$ 48.00

Cayman Chemical
REV 5901 ≥98%
5mg
$ 25.00

ApexBio Technology
REV5901
10mg
$ 67.00

ApexBio Technology
REV5901
50mg
$ 277.00

ApexBio Technology
REV5901
100mg
$ 485.00

American Custom Chemicals Corporation
REV 5901 95.00%
5MG
$ 431.50

American Custom Chemicals Corporation
REV 5901 95.00%
100MG
$ 926.00

Total 10 raw suppliers

Chemical Property of alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol

Chemical Property:

Vapor Pressure:1E-10mmHg at 25°C
Refractive Index:1.606
Boiling Point:497.7 °C at 760 mmHg
PKA:14.48±0.20(Predicted)
Flash Point:254.8 °C
PSA：42.35000
Density:1.123 g/cm³
LogP:5.42750
Solubility.:≤100mg/ml in ethanol;100mg/ml in methanol;100mg/ml in acetone;100mg/ml in DMSO;100mg/ml in etonitrile.
XLogP3:5.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:335.188529040
Heavy Atom Count:25
Complexity:375

Purity/Quality:

98%min ^*data from raw suppliers

L-655,238 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCCC(C1=CC(=CC=C1)OCC2=NC3=CC=CC=C3C=C2)O
Description REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 μM.
Uses REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 μM. L-655,238 is a potent and selective inhibitor of FLAP (5-LO-activating protein).

Technology Process of alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol

There total 9 articles about alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 4377-41-7
2-Chloromethylquinoline

: 92532-21-3
1-(3-hydroxyphenyl)-1-hexanol

: 101910-24-1
2-[3-(1-hydroxyhexyl)phenoxymethyl]quinoline

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 20h;
DOI:10.1021/jo00064a043

Reference yield:

: 121-71-1
3-Hydroxyacetophenone

: 101910-24-1
2-[3-(1-hydroxyhexyl)phenoxymethyl]quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1 h, 2) THF, -78 deg C, 0.3 h

2: 80 percent / p-toluenesulfonic acid monohydrate, 3 Angstroem molecular sieves / toluene / 22 h / 40 °C

3: 98 percent / H₂ / 10percent Pd-C / ethanol / 1 h / 25 °C / 760 Torr

4: 86 percent / K₂CO₃ / dimethylformamide / 20 h / 75 °C

With 3 A molecular sieve; hydrogen; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00064a043

Reference yield:

: 147919-69-5
trans-3-(3-hex-2-enoyl)phenol

: 101910-24-1
2-[3-(1-hydroxyhexyl)phenoxymethyl]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / 10percent Pd-C / ethanol / 1 h / 25 °C / 760 Torr

2: 86 percent / K₂CO₃ / dimethylformamide / 20 h / 75 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00064a043