(2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol

Base Information

Chemical Name:(2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol
CAS No.:1404098-80-1
Molecular Formula:C₂₄H₃₄O₃Si
Molecular Weight:398.618
Hs Code.:

Synonyms:(2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol

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Chemical Property of (2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol

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Technology Process of (2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol

There total 1 articles about (2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1404098-74-3
(2S,3S)-3-(dimethyl(phenyl)silyl)-1-methoxyhex-4-yn-2-ol

: 35106-82-2
2-vinylbenzylalcohol

: C₁₅H₂₄O₂Si

: C₃₀H₄₆O₄Si₂

: 1404098-80-1
(2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol

Guidance literature:: (2S,3S)-3-(dimethyl(phenyl)silyl)-1-methoxyhex-4-yn-2-ol; With triisopropoxytitanium(IV) chloride; n-butyllithium; cyclopentylmagnesium chloride; In diethyl ether; hexane; at -78 - 0 ℃; for 2h; Inert atmosphere;

2-vinylbenzylalcohol; With n-butyllithium; In diethyl ether; hexane; at -78 - 0 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja3083945

Reference yield: 85.0%

: 1404098-80-1
(2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol

: 1404099-07-5
2-((5S,6S,E)-5-(dimethyl(phenyl)silyl)-6-hydroxy-7-methoxy-3-methylhept-3-en-1-yl)benzaldehyde

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ja3083945

Reference yield:

: 1404098-80-1
(2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol

: 1404099-15-5
(S)-1-((2S,3R,3aS,9bS)-3-(dimethyl(phenyl)silyl)-3a-methyl-2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]furan-2-yl)-2-methoxyethanol

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / dichloromethane / -40 - -30 °C / Inert atmosphere

With manganese(IV) oxide; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1021/ja3083945