(S)-1-((2S,3R,3aS,9bS)-3-(dimethyl(phenyl)silyl)-3a-methyl-2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]furan-2-yl)-2-methoxyethanol

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Chemical Name:(S)-1-((2S,3R,3aS,9bS)-3-(dimethyl(phenyl)silyl)-3a-methyl-2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]furan-2-yl)-2-methoxyethanol
CAS No.:1404099-15-5
Molecular Formula:C₂₄H₃₂O₃Si
Molecular Weight:396.602
Hs Code.:

Synonyms:(S)-1-((2S,3R,3aS,9bS)-3-(dimethyl(phenyl)silyl)-3a-methyl-2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]furan-2-yl)-2-methoxyethanol

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Chemical Property of (S)-1-((2S,3R,3aS,9bS)-3-(dimethyl(phenyl)silyl)-3a-methyl-2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]furan-2-yl)-2-methoxyethanol

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Technology Process of (S)-1-((2S,3R,3aS,9bS)-3-(dimethyl(phenyl)silyl)-3a-methyl-2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]furan-2-yl)-2-methoxyethanol

There total 2 articles about (S)-1-((2S,3R,3aS,9bS)-3-(dimethyl(phenyl)silyl)-3a-methyl-2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]furan-2-yl)-2-methoxyethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1404099-07-5
2-((5S,6S,E)-5-(dimethyl(phenyl)silyl)-6-hydroxy-7-methoxy-3-methylhept-3-en-1-yl)benzaldehyde

: 1404099-15-5
(S)-1-((2S,3R,3aS,9bS)-3-(dimethyl(phenyl)silyl)-3a-methyl-2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]furan-2-yl)-2-methoxyethanol

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -40 - -30 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja3083945

Reference yield:

: 1404098-80-1
(2S,3S,E)-3-(dimethyl(phenyl)silyl)-7-(2-(hydroxymethyl)phenyl)-1-methoxy-5-methylhept-4-en-2-ol

: 1404099-15-5
(S)-1-((2S,3R,3aS,9bS)-3-(dimethyl(phenyl)silyl)-3a-methyl-2,3,3a,4,5,9b-hexahydronaphtho[1,2-b]furan-2-yl)-2-methoxyethanol

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / dichloromethane / -40 - -30 °C / Inert atmosphere

With manganese(IV) oxide; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1021/ja3083945