2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile

Base Information

• Chemical Name: 2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile
• CAS No.: 82127-09-1
• Molecular Formula: C₁₆H₈BrClN₂S
• Molecular Weight: 375.676
• Mol file: 82127-09-1.mol

Synonyms:2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile

Chemical Property of 2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile

There total 3 articles about 2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile (82137-59-5) → 2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile (82127-09-1)

Guidance literature:

With bromine; acetic acid; at 60 - 70 ℃; for 3h;

DOI:10.1021/ci400723m

Reference yield:

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione (326-91-0) → 2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile (82127-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / morpholine / ethanol / 2 h / Heating

2: 69 percent / Br₂ / acetic acid / 65 - 80 °C

With morpholine; bromine; In ethanol; acetic acid;

Reference yield:

4-chlorobenzylidenemalonodinitrile (1867-38-5) → 2-bromo-4-(4-chlorophenyl)-6-(2-thienyl)-3-pyridinecarbonitrile (82127-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / morpholine / ethanol / 2 h / Heating

2: 69 percent / Br₂ / acetic acid / 65 - 80 °C

With morpholine; bromine; In ethanol; acetic acid;

upstream raw materials:

3-(4-chlorophenyl-1-(2-thienyl)-3-oxopropyl)propanedinitrile

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

4-chlorobenzylidenemalonodinitrile

Downstream raw materials:

4-(4-chlorophenyl)-2-(4-morpholinyl)-6-(2-thienyl)-3-pyridinecarbonitrile

4-(4-chlorophenyl)-2-(1-piperidinyl)-6-(2-thienyl)-3-pyridinecarbonitrile

4-(4-chlorophenyl)-2-[1-(4-methylpiperazinyl)]-6-(2-thienyl)-3-pyridinecarbonitrile

4-(4-chlorophenyl)-2-[1-(4-ethylpiperazinyl)]-6-(2-thienyl)-3-pyridinecarbonitrile