ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate

Base Information

Chemical Name:ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate
CAS No.:104885-01-0
Molecular Formula:C₁₄H₁₁F₄NO₆
Molecular Weight:365.238
Hs Code.:

Synonyms:ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate

Suppliers and Price of ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate

There total 4 articles about ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 103772-11-8
2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester

: 122-51-0
orthoformic acid triethyl ester

: 104885-01-0
ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate

Guidance literature:: With acetic anhydride; for 3h; Heating;
DOI:10.1021/jm00107a039

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 104885-01-0
ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / fuming HNO₃, H₂SO₄ / 5.5 h / 70 °C

2: oxalyl chloride, DMF / CH₂Cl₂ / 16 h

3: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h

4: 95 percent / Ac₂O / 3 h / Heating

With n-butyllithium; dipyridyl; oxalyl dichloride; sulfuric acid; nitric acid; acetic anhydride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00107a039

Reference yield:

: 16583-08-7
2,3,4,5-tetrafluoro-6-nitrobenzoic acid

: 104885-01-0
ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 16 h

2: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h

3: 95 percent / Ac₂O / 3 h / Heating

With n-butyllithium; dipyridyl; oxalyl dichloride; acetic anhydride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00107a039